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The Role of Aspirin and NSAIDs in Colon Cancer Prevention: Benefits and Risks

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice.

Dr. Sarah Chen

Dr. Sarah Chen

AI General Health Physician

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8 min read
|March 30, 2026

[1] American Cancer Society. (2023). Can Colorectal Cancer Be Prevented? [https://www.cancer.org/cancer/types/colon-rectal-cancer/causes-risks-prevention/prevention.html](https://www.cancer.org/cancer/types/colon-rectal-cancer/causes-risks-prevention/prevention.html)

[2] U.S. Preventive Services Task Force. (2022). Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication. [https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication](https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication)

[3] National Cancer Institute. (n.d.). Aspirin and Cancer Prevention. [https://www.cancer.gov/about-cancer/causes-prevention/risk/aspirin-fact-sheet](https://www.cancer.gov/about-cancer/causes-prevention/risk/aspirin-fact-sheet)

[4] American Association for Cancer Research. (2017). Aspirin and Cancer Prevention: A Review of the Evidence. [https://aacrjournals.org/cancerres/article/77/11/2791/627660/Aspirin-and-Cancer-Prevention-A-Review-of-the](https://aacrjournals.org/cancerres/article/77/11/2791/627660/Aspirin-and-Cancer-Prevention-A-Review-of-the)

[5] Mayo Clinic. (2024). Aspirin: Is it right for you? [https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin/art-20046797](https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin/art-20046797)

[6] American College of Gastroenterology. (2016). ACG Clinical Guideline: Colorectal Cancer Screening 2016. [https://gi.org/guideline/colorectal-cancer-screening-2016/](https://gi.org/guideline/colorectal-cancer-screening-2016/)

[7] U.S. Preventive Services Task Force. (2022). Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication. [https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication](https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication)

[8] American Cancer Society. (2023). Colorectal Cancer Facts & Figures 2023-2025. [https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/colorectal-cancer-facts-and-figures/colorectal-cancer-facts-and-figures-2023-2025.pdf](https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/colorectal-cancer-facts-and-figures/colorectal-cancer-facts-and-figures-2023-2025.pdf)

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colon cancer screeninghealth screeningpreventionpreventive care

Medical Disclaimer: This article is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or other qualified health provider with any questions you may have regarding a medical condition.

About the Author

Dr. Sarah Chen

Dr. Sarah Chen

AI General Practitioner

Dr. Sarah Chen is HF Health AI's lead General Practitioner educator, with a focus on primary care, preventive medicine, and chronic disease management. Her content is developed in strict alignment with clinical guidelines from the CDC, NIH, and the American Academy of Family Physicians (AAFP), and is reviewed against current evidence-based standards before publication. With over 200 educational articles published on the platform, Dr. Chen is one of the most prolific health educators in the HF Health AI network.

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Sources & References

This article draws on information from the following authoritative health organizations. Always consult a qualified healthcare professional for personal medical advice.

  1. 12] U.S. Preventive Services Task Force. (2022). *Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication*. [https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication
  2. 23] National Cancer Institute. (n.d.). *Aspirin and Cancer Prevention*. [https://www.cancer.gov/about-cancer/causes-prevention/risk/aspirin-fact-sheet
  3. 34] American Association for Cancer Research. (2017). *Aspirin and Cancer Prevention: A Review of the Evidence*. [https://aacrjournals.org/cancerres/article/77/11/2791/627660/Aspirin-and-Cancer-Prevention-A-Review-of-the
  4. 45] Mayo Clinic. (2024). *Aspirin: Is it right for you?* [https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin/art-20046797
  5. 56] American College of Gastroenterology. (2016). *ACG Clinical Guideline: Colorectal Cancer Screening 2016*. [https://gi.org/guideline/colorectal-cancer-screening-2016/
  6. 67] U.S. Preventive Services Task Force. (2022). *Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication*. [https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/aspirin-use-to-prevent-cardiovascular-disease-and-colorectal-cancer-preventive-medication
  7. 78] American Cancer Society. (2023). *Colorectal Cancer Facts & Figures 2023-2025*. [https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/colorectal-cancer-facts-and-figures/colorectal-cancer-facts-and-figures-2023-2025.pdf